Signal processing underlying memory and spatial navigation
The hippocampus and entorhinal cortex, which are part of the medial temporal lobe (MTL), support memory and spatial navigation functions. Our research focuses on neural computation underlying cognitive functions of the MTL, combining in vitro and in vivo electrophysiological recordings with computational simulations. Since the MTL is crucially involved in Alzheimer’s disease and temporal lobe epilepsy, studying neural computation in the MTL is central not only to understanding of cognitive functions and its engineering applications, but also to developing treatments for dementia and epilepsy.
We study electrophysiological characteristics of neurons as a fundamental element of cognitive function using in vitro patch clamp recordings.
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Activity of the brain is monitored during cognitive behavior using in vivo unit recordings.
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Computational simulations are used for testing new ideas and confirming empirical data.
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News
10.03.2021: New Publication from the lab: Valero-Aracama MJ, Reboreda A, Arboit A, Sauvage M, Yoshida M (2021) Noradrenergic Suppression of Persistent Firing in Hippocampal CA1 Pyramidal Cells through cAMP-PKA Pathway. eNeuro, 8(2).
05.02.2020: New Publication from the Lab: Arboit A, Reboreda A, Yoshida M (2020) Involvement of TRPC4 and 5 channels in persistent firing in hippocampal CA1 pyramidal cells, Cells, 9(2).
02.01.2019: New Publication from the Lab: Knauer B, Yoshida M (2019) Switching between persistent firing and depolarization block in individual rat CA1 pyramidal neurons. Hippocampus, Accepted.
08.26. 2018: New PhD positions are available through DFG and CBBS grants.
03.03.2018: New publication - Spatial information is preferentially processed by the distal part of CA3: implication for memory retrieval.
03.03.2018: New publication - Do TRPC channels support working memory?: Comparing modulations of TRPC channels and working memory through G-protein coupled receptors and neuromodulators
05.02.2020: New Publication from the Lab: Arboit A, Reboreda A, Yoshida M (2020) Involvement of TRPC4 and 5 channels in persistent firing in hippocampal CA1 pyramidal cells, Cells, 9(2).
02.01.2019: New Publication from the Lab: Knauer B, Yoshida M (2019) Switching between persistent firing and depolarization block in individual rat CA1 pyramidal neurons. Hippocampus, Accepted.
08.26. 2018: New PhD positions are available through DFG and CBBS grants.
03.03.2018: New publication - Spatial information is preferentially processed by the distal part of CA3: implication for memory retrieval.
03.03.2018: New publication - Do TRPC channels support working memory?: Comparing modulations of TRPC channels and working memory through G-protein coupled receptors and neuromodulators
Funding
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Dr. Motoharu Yoshida | AG Cognitive Neurophysiology | Leibniz Institute for Neurobiology | German Center for Neurodegenerative Diseases | Magdeburg
